Twisynt Technologies Pvt Ltd: Advancing Research in Non-Invasive Potassium Monitoring for CKD Patients

Twisynt Technologies Private Limited, founded by Vismaya S, is an emerging medtech R&D organization based at MSMF, Mazumdar Shaw Medical Center, Hosur Rd, Bommasandra Industrial Area, Bengaluru. The company is currently conducting focused research and development on TinySense, a next-generation wearable designed to offer continuous, non-invasive potassium monitoring for individuals with Chronic Kidney Disease (CKD) and dialysis-dependent conditions.

Research Background: Potassium Variability in CKD

Potassium homeostasis is critically impaired in CKD due to declining renal clearance, altered cellular exchange, dietary restrictions, and dialysis-related shifts. Numerous studies have established that:

Hyperkalemia contributes significantly to mortality in advanced CKD.
Potassium fluctuations often occur between clinical visits.
Existing point-in-time tests cannot capture dynamic changes.

This creates a need for more granular, continuous monitoring tools that can reveal trends and early deviations.

TinySense: Investigating a Non-Invasive Approach to Potassium Surveillance

Current research at Twisynt Technologies focuses on integrating sensor-based, non-invasive detection methods capable of tracking potassium levels continuously. The goal is to generate real-time electrolyte trend data without dependence on serum sampling.

Research-Centric Features

• Continuous data acquisition
TinySense aims to capture potassium dynamics throughout daily activities, enabling longitudinal monitoring rather than episodic measurements.

• Non-invasive sensor research
Development includes exploring mechanisms that correlate surface-level physiological changes with potassium fluctuations.

• Signal interpretation and trend prediction
Machine-learning–assisted models are being evaluated to enhance the interpretation of collected data and identify pre-symptomatic changes.

• Potential to support early intervention
By identifying shifts before symptomatic manifestation, the device may aid researchers and clinicians in preventing complications.

Relevance to Ongoing Nephrology Research

Potassium dysregulation remains one of the most urgent clinical challenges in CKD and dialysis care. Research suggests that continuous monitoring could help:

Characterize inter-dialytic potassium behavior
Improve understanding of patient-specific variability
Reduce emergency events related to undetected hyperkalemia
Provide insights for future precision-medicine approaches in nephrology

TinySense contributes to this landscape by exploring wearable, patient-friendly sensing pathways.

Interdisciplinary Development Approach

Under the leadership of Founder & Director Vismaya S, Twisynt Technologies applies an interdisciplinary framework involving:

Biomedical sensor research
Data modeling and signal processing
Human factors engineering
Clinical collaboration for validation pathways

This approach ensures that TinySense development aligns with both scientific rigor and patient usability.

Location

R&D Facility:
MSMF, Mazumdar Shaw Medical Center
Hosur Rd, Bommasandra Industrial Area, Bengaluru, Karnataka 560099

Website: twisynt.com